Pathogenesis of sepsis pdf printer

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As depicted in Figure 1, on the cellular and molecular levels, the pathogenesis of sepsis is extremely complex, including imbalance in inflammatory response, immune dysfunction, mitochondrial damage, coagulopathy, neuroendocrine immune network abnormalities, endoplasmic reticulum stress, autophagy, and other pathophysiological processes, and ult While insights in the pathogenesis of sepsis have rapidly grown, this com-plex syndrome is not yet fully understood, and our increased understanding of pathophysiological mechanisms underlying sepsis has thus far failed to improve health outcome. This chapter provides a brief overview of the pathogenesis of sepsis (Fig. 3.1). 32 3.2 Pathogens and Infection Sites A successful pathogen must