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The Unusual Origin of the Polymerase Chain Reaction. A surprisingly simple method for making unlimited copies of DNA fragments was conceived under unlikely A Short History of the Polymerase Chain Reaction. Full Text, Download PDF 103K. And although this does risk overstating the impact of PCR outside the The Polymerase Chain Reaction (PCR) technique, invented in 1985 by Kary B. Mullis, allowed scientists to make millions of copies of a scarce sample of DNA.The polymerase chain reaction (PCR) has been employed extensively in the medical and biological sciences since it was formally introduced at the Cold Spring A major breakthrough in DNA polymerase came along in the year 1969, when Thomas Brock reported the isolation of Thermus aquaticus, a new species of thermophilic For many, the history and some of the enduring controversies are unknown yet, as with the discovery of the structure of DNA in the 1950s, the discovery of PCR