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Key Words: Anal fissure; Fissure-in-ano; Sphincterotomy. Dis Colon Rectum 2010; 53: 1110 –1115 view54 show that LIS is superior to uncontrolled manual.these guidelines were built on the last set of the american society of Colon and Rectal surgeons practice parameters for treatment of fissure-in-ano published